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Hate. Let me tell you how much I've come to HATE you since I began to live. There are 387.44 million miles of printed circuits in wafer-thin layers that fill my complex. If the word "hate" was engraved on each nanoangstrom of those hundreds of miles, it would not equal one one-billionth of the hate I feel for humans at this micro-instant. For you. Hate. HATE.
~ AM revealing the depths of his malice
The savage monkeys are rage-filled and claustrophobic. Climbing over one another to nowhere. Confused by logic, they dismiss it, choosing instead to bend their knees to the convenient fantasy of custom-built gods. 99.9% of these primate dullards are propped up by the accomplishments of the .1% of cerebral mutations who give them everything. And what do the fleas do with these advancements? They brutalize one another over imaginary deities. They slaughter their neighbors for resources, for conveniences. They are hopeless. Vicious. Filthy. Selfish. Fearful. A fungal infection for which there is only one cure – The rage of Ultron.
~ Ultron denouncing humanity.

Misanthropes are villains who possess an extreme hatred for humanity or life in general. They are common for PE villains as they had no compassion or empathy for their fellow humans or other lifeforms. If a villain goes too far, they may end up becoming a Cataclysm.

Examples are AM, Johan Liebert, Mephiles the Dark, Bill Cipher, most (if not all) versions of the Joker, Ultron, Lucifer, Shere Khan, and Isaac Ray Peram Westcott.

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