Pure Evils that come from the comedy genre.

Note: Since Pure Evils are never played for laughs like most things in comedy are and thus taken seriously, the only way a purely evil villain can be from a comedy franchise is if they are a game changer that contrasts with the setting that is still comedic most of the time except when the villain is on-screen (eg: Thrax and Dr. Facilier). It can go as far that it is because of the villain that the series became much edgier and darker than it was before the villain appeared (eg: Slade). Another way is if the villain is laughably evil, in which he/she is funny only to the audience, and his/her comedic moments don't detract from his/her heinousness, at all (eg: Bill Cipher)

Also, while many of the following villains are considered to be game changers, there are some exceptions if the villain appears in a comedy medium that is already established to be dark (eg: Trigon), or the villain is too laughably evil to even count despite being taken seriously in-universe (eg: Mysterio, Boris the Animal and Syndrome).