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We must seek the balance, Megatron. Not only between the organic and the technological, but the balance between eternal enemies: between you and I!
~ Optimus Primal sacrificing himself and his sworn enemy, Megatron, to bring true balance to Cybertron.
You won't kill me, out of some misplaced sense of self-righteousness... and I won't kill you, because you're just too much fun! I think you and I are destined to do this forever.
~ The Joker analyzing his relationship with Batman.

These are Pure Evil villains who also serve as the main enemies of the protagonists, standing out from the rest of the heroes' enemies y either being a total antithesis of the hero, their strongest enemies, have the strongest connections to the heroes' past, their most personal enemy, or the most recurring threat they fight.

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