I'm not saying I actually feel any type of sympathy for these people, nor will I attempt any type of Draco In Leather Pants bullshit because they are irredeemable psychopaths. I just mean that these are characters that would come close to being Jerkass Woobies if they had redeeming qualities.
Griffith:
This is a pretty obvious one. He was genetically bred to be sociopathic and environmentally manipulated from birth to join the Godhand while believing he was enacting free-will, he decided upon a completely meaningless goal (muh kingdom) as a child that he never allowed himself to waver on regardless of the cost to himself or others when he was inches away from realizing that instead of getting a castle he should have torn the castle down, he was raped as a child (He "consented" but he couldn't have been older than 15 at the time and he literally started cutting himself afterwards from the trauma), and he was irreversibly crippled after being tortured and raped for 2 years, but all sympathy for him goes out the window as soon as he refuses to realize the cartoonishly obvious "POWER OF FRIENDSHIP" directly in front of him and especially when he violently rapes one of his closest comrades in front of the other's eyes and then continues going from there.