I just want to know this for sure, because I still believe that Belos’ murder of Luz when attempting to kill Collector is MEH because it shows that he’s beyond redemption even when a god-like being shows him mercy
Back to the question, I think it's when the murder is preceded by torture/beating/rape, when the victim is a small child or when the death itself is really gruesome.
Because int he cases of Odalia and Kikimora's had theirs happen in the beginning of their arcs, with the former to show she is more than a "mere" karen, and the latter to show she ain't loyl to the Coven.
Belos on the other hand, had "Hollow Mind" already out to establish how much of a horrid and unreasonable excuse of a human being is. They are very different scenarios