Crossed is a comic series is a comic series by Garth Ennis (tbh I could probably stop here). It focuses on an infection which turns people inti the worst possible version of themselves, meaning if someone has a desire to murder, torture, cannibalize, or worse, they will do it.
To give you an idea of how high the Crossed heinous standard is, Joe Pratt, a man who raped his own daughters multiple times and even forced his son to do the same, and Harold Lorre, a necrophiliac serial killer who tortures, rapes, and kills at least 4 people, are both Villainous Benchmarks. Every antagonist is a either a cannibal, serial rapist, torturer, mass murderer, or all four. Who in this wiki could possibly stand out?